Table 2. p53+/R172H mice manifested macrocytic anemia, but less frequently with PML depletion.
| mean values | C57BL.6 | PML−/− | p53+/R172H PML+/+ | p53+R172H PML+/− | p53+/R172HPML−/− | ||
|---|---|---|---|---|---|---|---|
| normal HGB | low HGB | normal HGB | low HGB | ||||
|
HGB (g/L) |
145 | 141.3 | 64.00 | 131.2 | 65.0 | 142.8 | 33.5 |
| p-value | ns 0.7355 | s < 0.0001 | ns 0.0490 | s < 0.0001 | ns 0.8304 | s < 0.0001 | |
| MCV (fL) | 51.11 | 49.90 | 59.41 | 49.28 | 64.28 | 50.56 | 62.01 |
| p-value | ns 0.3239 | s 0.0307 | ns 0.2110 | s 0.0027 | ns 0.7131 | s 0.0252 | |
| RBC | 9.078 | 8.775 | 4.281 | 8.106 | 3.583 | 8.628 | 2.195 |
| p-value | ns 0.4893 | s 0.0002 | s 0.0120 | s < 0.0001 | ns 0.4722 | s < 0.0001 | |
| WBCs (10 9 /L) | 3.317 | 4.138 | 9.250 | 7.276 | 5.700 | 6.139 | 8.215 |
| p-value | ns 0.3578 | s 0.0113 | ns 0.1583 | s 0.0394 | ns 0.3062 | ns 0.1419 | |
| No. mice | 9 | 4 | 15 | 17 | 5 | 18 | 10 |
Normal ranges: HGB 118–149 g/L; MCV 42.2–59.2 fL; RBC 7–10 × 1012/L; WBC 3–13 × 109/L ADVIA. *Significance (s) or no significance (ns) was determined using the unpaired t-test; p < 0.05,where all values were compared with C57BL.6.