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Figure 7. CA IX silencing in CAFs decreases tumor growth and lung micrometastasis formation. (A) Xenograft growth in SCID bg/bg mice of wild-type (control) or CA IX-silenced CAFs injected s.c. with PCa cells (CAFs:PCa cells ratio 1:5). (B) Bar graph shows the mean of lung micrometastasis. (C) Representative images of lung micrometastasis (arrows) in control and CA IX silenced treated mice. (D) Ca IX silencing by RNA interference in CAFs is shown. *p < 0,001 vs. control.
