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. Author manuscript; available in PMC: 2014 May 8.
Published in final edited form as: J Am Chem Soc. 2013 Apr 29;135(18):6766–6769. doi: 10.1021/ja400994e

Figure 1.

Figure 1

Schematic of the equilibrium between a G•C WC and HG base pair. (a) The transition from a ground state WC to a transient state HG base pair, with relative populations measured by NMR relaxation dispersion,3 requires an anti-to-syn rotation around the glycosidic bond (χ) and creates a stabilizing H-bond upon C N3 protonation. (b) Methylation at G N1 favors formation of a ground state HG base pair at pH 5.2.3