Figure 7.

Fourth ventricle injection of calcineurin inhibitor CsA potentiates CCK-induced reduction of food intake. A, Cumulative food intake in 16-hour food-deprived rats at 30, 60, 120, and 240 minutes after an ip of CCK (2 μg/kg) or saline administration preceded by a fourth ventricle injection of CsA (12 μg) or vehicle 1 hour prior to the ip injections. Meal size (B) and postmeal interval (C) for the first four meals after the return of food. Data are means ± SEM. Means sharing a common letter do not differ significantly.