Food intake, body weight, body fat, and lean body mass of rats from experiment 1 infused with saline (SS), low-dose leptin in either third or fourth ventricle (LS or SL), or low-dose leptin in both ventricles (LL) for 12 days. Data are means ± SEM for 9 rats. *, Significant difference between rats infused in both ventricles (LL) and all other groups (SS, LS, and SL) at P < .05. Data for body fat or lean body mass that do not share a common superscript are significantly different at P < .05.