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. 2013 Jun 4;154(8):2821–2832. doi: 10.1210/en.2013-1156

Figure 3.

Figure 3.

CART depolarizes Kiss1-GFP neurons in the mouse. (A) A representative current-clamp recording showing spontaneous firing in Kiss1 neurons and CART induced depolarization under no presynaptic input block condition. The resting membrane potential was −63 mV. (B) Histogram for the representative recording shown in (A) showing firing increased from 1.4 to 3.64 events per minute. (C) A representative current-clamp recording under TTX showing 30 nM CART induced depolarization. The resting membrane potential was −65 mV. (D) Summary of the significant depolarizing effect of CART in the presence of TTX (control, −62.2 ± 5.06 mV; CART, −48.7 ± 3.4 mV; P < .005).