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Activity in the medial prefrontal cortex as a function of symptom severity. A negative correlation was found in children with autism spectrum disorders between activity in the medial prefrontal cortex and scores on the Social Responsiveness Scale (higher scores indicate greater social impairment). Activation exceeds thresholds of P<.05 corrected for multiple comparisons at the cluster level (k≥115) and P<.05 at the voxel level (t>2.57 at peaks).
