Table 4.

Peaks of Activation During Irony Conditions^*

			Neutral Instructions vs Rest								Attend to Face or Prosody vs Rest
			TD Group				ASD Group				TD Group				ASD Group
Anatomical Region	Putative BA	H	x	y	z	t Score	x	y	z	t Score	x	y	z	t Score	x	y	z	t Score
Medial prefrontal cortex	8	L									−6	40	48	4.41
	9	L	−10	58	28	4.92					−6	52	30	3.97	−8	52	32	3.35
	9	R	2	50	20	3.85
	10	L	−2	62	18	7.44					0	62	20	6.69
	10	R													4	58	14	3.13
Precentral gyrus	6	R	48	2	34	3.80									34	2	36	4.34
Middle frontal gyrus	9	R													40	12	38	3.64
	46	L									−44	42	4	3.29
Inferior frontal gyrus	44	L	−58	18	16	3.23					−56	16	14	3.59	−50	14	26	3.25
	44	R	32	14	22	3.79†					50	18	24	4.19†	52	16	16	3.93
	45	L	−56	22	20	2.91					−56	18	8	5.67	−52	20	18	3.35
	45	R	50	24	10	5.30†					50	24	16	5.51†	40	30	0	5.27
	47	L	−44	22	−10	4.73					−48	30	−2	6.16
Transverse temporal gyrus	41/42	L	−48	−30	8	10.11	−66	−32	10	6.41	−52	−28	6	10.99	−40	−32	14	3.38
	41/42	R	48	−24	6	9.06	52	−26	10	6.10	52	−20	10	7.65	54	−24	6	6.48
Superior temporal gyrus	22	L	−60	−22	2	10.61	−56	−30	2	8.01	−58	−22	4	16.63	−54	−20	4	6.31
	22	R	54	−8	−2	12.63	56	−6	−2	4.72	50	−10	0	9.44	50	−20	2	6.92
Middle temporal gyrus	21	L	−58	−4	−8	6.10	−60	−54	10	4.66	−66	−30	0	8.25	−56	−46	6	8.65
	21	R	46	−38	2	5.74	54	−50	4	3.77	54	−6	−4	11.10	54	−2	−8	5.46
	37	L									−54	−68	8	4.63	−46	−62	10	6.29
	37	R	50	−60	10	4.52	48	−62	6	5.75	52	−58	10	4.42	46	−62	6	6.00
	39	L	−48	−66	14	3.36	−52	−64	18	3.90	−48	−66	12	5.11	−44	−60	20	3.13
	39	R	38	−70	16	3.37	52	−60	20	3.16	38	−68	12	6.29
Temporal pole	38	L	−42	16	−18	2.88					−46	10	−26	4.55	−56	6	−10	5.23
	38	R	38	16	−20	6.90	52	2	−8	3.23	40	14	−20	7.51	40	10	−26	6.27
Fusiform gyrus	37	L	−40	−44	−14	4.40	−40	−62	−16	4.71	−44	−48	−12	12.18	−40	−50	−10	7.30
	37	R	38	−48	−14	5.04	36	−46	−14	4.04	32	−46	−16	4.52	40	−54	−10	6.09
	19	L	−32	−80	−8	6.34	−34	−70	−14	5.48	−32	−56	−10	5.91	−32	−78	−8	6.04
	19	R	26	−74	−10	3.67	36	−60	−8	5.68	40	−48	−8	6.92	28	−76	−10	5.84
Lingual gyrus	18	L	−26	−78	−6	5.61	−24	−82	−2	4.95	−20	−82	−4	8.85	−22	−80	−8	6.81
	18	R	24	−80	0	7.96	12	−86	0	6.38	22	−78	−2	8.51	16	−80	0	6.63
Middle occipital gyrus	19	L	−32	−88	8	6.97	−46	−84	10	3.91	−32	−86	8	7.61	−46	−84	8	7.08
	19	R	28	−82	4	8.18	34	−82	8	4.68	30	−84	8	10.65	40	−74	4	5.89
Inferior occipital gyrus	17/18	L	−36	−84	−4	10.55	−30	−92	4	6.88	−34	−82	−4	9.51	−28	−86	−6	8.02
	17/18	R	38	−76	−2	7.50	14	−90	−4	4.06	40	−74	0	9.42	20	−88	2	6.80
Cuneus	18	L	−12	−94	20	3.39	−18	−94	12	4.03	−4	−92	12	7.30	−8	−92	10	2.59
	18	R	10	−90	14	4.86	18	−88	10	6.07	16	−88	10	6.73	16	−92	12	6.08
Cerebellum		L	−28	−74	−28	5.34					−26	−72	−32	5.12	−30	−70	−26	3.90
		R	12	−80	−20	5.71					16	−66	−20	4.08

Abbreviations: ASD, autism spectrum disorders; BA, Brodmann area; H, hemisphere; L, left; R, right; TD, typical development.

^*Thresholds were P<.05 corrected for multiple comparisons at the cluster level (k ≥115 voxels) and P<.05 at the voxel level (t>2.57 at peak).

^†Survive only a small volume correction (k ≥55 voxels).