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SEA in siRNA-treated animals is exaggerated by C-fiber activation. Recording from an siRNA-treated animal strand, featuring a small unit firing spontaneously (arrowhead). After stimulation at A-fiber strength (2 Hz), a second previously silent unit is recruited and shows progressive SEA (top, double arrowheads). This phenomenon was exaggerated when delivering stimuli capable of activating C-fibers, even at low frequencies (1 Hz, bottom).
