Table 1.
Authors | Population characteristics | Domains assessed | MCI definition | Prevalence PD-MCI | Cognitive profile found |
---|---|---|---|---|---|
Aarsland et al., 2009 [67] | Community-based incidental cohort, 196 nondemented, drug-naïve PD patients | Verbal memory Visuospatial ability Attention, executive function |
≥1.5 SD below z score in at least 1 of 3 domains | 18.9% | 86.5% SD-MCI 62.2% Nonamnestic 24.3% Amnestic 13.5% MD-MCI 2.7% Nonamnestic 10.8% Amnestic |
Foltynie et al., 2004 [32] |
Incident cohort of 142 PD patients | Executive function Spatial memory Pattern recognition memory |
≥1 SD below normative data in ≥1 test | 35.2% | 58% SD-MCI 34% Frontostriatal deficits 24% Temporal lobe deficits 42% MD-MCI (frontostriatal and temporal deficits) |
Mamikonyan et al., 2009 [19] |
106 PD patients, convenience sample with intact global cognition based on age- and education-adjusted MMSE score | Memory Executive function Attention |
≥1.5 SD below normative data in ≥1 domain | 29.2% | 61.3% SD-MCI 29% Attention 19.3% Amnestic 13% Executive 38.7% MD-MCI |
Muslimović et al., 2005 [20] | 115 newly diagnosed PD patients without “global cognitive deterioration” defined as an MMSE score <24 | Executive function Memory Attention Language Visuospatial |
≥2 SD below normative data on ≥3 neuropsychological tests | 23.5% | MCI subtypes not described |
SD-MCI: single-domain mild cognitive impairment. MD-MCI: multiple-domain mild cognitive impairment.