Table 1.
Clinical and biological data at admission in ICU according to the diagnosis of sepsis and its severity.
| Characteristics | All SIRS | All sepsis | P value | Sepsis | Severe sepsis | Septic shock | P value |
|---|---|---|---|---|---|---|---|
| N = 30 | N = 100 | N = 36 | N = 35 | N = 29 | |||
| Age (years) | 52.2 ± 20.4 | 58.9 ± 19.5 | 0.105 | 57.2 ± 19.9 | 55.3 ± 18.5 | 65.4 ± 19.1 | 0.094 |
| Gender (n, %) | 0.091 | 0.753 | |||||
| Male | 15 (50) | 67 (67) | 23 (63.9) | 23 (65.7) | 21 (72.4) | ||
| Female | 15 (50) | 33 (33) | 13 (36.1) | 12 (34.3) | 8 (27.6) | ||
| Temperature (°C) | 37.2 ± 0.6 | 37.8 ± 1.3 | <0.001 | 37.9 ± 1.1 | 38.0 ± 1.1 | 37.4 ± 1.6 | 0.112 |
| APACHE II score | 11.0 ± 7.0 | 13.4 ± 6.1 | <0.001 | 12.7 ± 6.4 | 18.4 ± 7.2 | 23.1 ± 5.4 | <0.001 |
| SOFA score | — | 7.8 ± 4.4 | — | 4.7 ± 3.0 | 7.3 ± 3.6 | 12.1 ± 3.0 | <0.001 |
| MV (n, %) | 23 (76.7) | 80 (80) | 0.693 | 24 (66.7) | 29 (82.9) | 27 (93.1) | 0.026 |
| CRRT (n, %) | 1 (3.3) | 22 (22) | 0.019 | 7 (19.4) | 8 (22.9) | 7 (24.1) | 0.892 |
| Possible etiological factors (n, %) | |||||||
| Pulmonary infection | — | 83 (83) | — | 30 (83.3) | 32 (91.4) | 21 (74.2) | 0.129 |
| Abdominal infection | — | 18 (18) | — | 6 (16.7) | 3 (8.6) | 9 (31) | 0.064 |
| Urinary tract infection | — | 24 (24) | — | 11 (30.6) | 6 (17.1) | 7 (24.1) | 0.417 |
| Trauma/postoperative infection | — | 31 (31) | — | 12 (33.3) | 10 (28.6) | 9 (31) | 0.154 |
| Bacteremia | — | 23 (23) | — | 12 (33.3) | 7 (20) | 4 (13.8) | 0.091 |
| Catheter-related infections | — | 13 (13) | — | 10 (27.8) | 1 (2.9) | 2 (6.9) | 0.004 |
| Others | — | 4 (4) | — | 0 (0) | 1 (2.9) | 3 (10.3) | 0.074 |
| Pathogens detected | |||||||
| Gram-positive bacteria | — | 37 (37) | — | 15 (41.7) | 8 (22.9) | 14 (48.3) | 0.085 |
| Gram-negative bacteria | — | 81 (81) | — | 31 (86.1) | 28 (80.0) | 22 (75.9) | 0.568 |
| Fungi | — | 62 (62) | — | 25 (69.4) | 21 (60.0) | 16 (55.2) | 0.471 |
| Predisposing factors (n, %) | |||||||
| Hypertension | 9 (30) | 41 (41) | 0.277 | 13 (36.1) | 18 (51.4) | 10 (34.5) | 0.295 |
| Diabetes | 2 (6.7) | 16 (16) | 0.319 | 3 (8.3) | 7 (20) | 6 (20.7) | 0.261 |
| COPD | 0 (0) | 14 (14) | 0.067 | 6 (16.7) | 3 (8.6) | 5 (17.2) | 0.493 |
| Coronary heart disease | 3 (10) | 17 (17) | 0.54 | 4 (11.1) | 3 (8.6) | 10 (34.5) | 0.016 |
| Immunosuppressed condition | 0 (0) | 11 (11) | 0.127 | 3 (8.3) | 8 (22.9) | 0 (0) | 0.004 |
| Nervous system disease | 0 (0) | 12 (12) | 0.103 | 5 (13.9) | 2 (5.7) | 5 (17.2) | 0.304 |
| CKD | 1 (3.3) | 8 (8) | 0.636 | 4 (11.1) | 2 (5.7) | 2 (6.9) | 0.687 |
| 28-day mortality rate (n, %) | 2 (5.0) | 43 (43.0) | P < 0.001 | 6 (16.7) | 17 (48.6) | 20 (69) | P < 0.001 |
Quantitative data of normal distribution are presented as mean ± SD. Quantitative data of nonnormal distribution are presented as median (interquartile range). Qualitative data are presented as n (%).
RICU: respiratory intensive care unit; SICU: surgical intensive care unit; EICU: emergency intensive care unit; MV: mechanical ventilation; CRRT: continuous renal replacement treatment; APACHE II score: acute physiologic assessment and chronic health evaluation II scores; SOFA score: sequential organ failure assessment scores; CKD: chronic kidney disease.