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Suppressor functions of MDSC
| Pathway | Effector molecule | Function | |
|---|---|---|---|
| Granulocyte-like subset | STAT3, NADPH | High ROS, Low NO, Arg-1 | Modification of T-cell receptor, antigen-specific unresponsiveness, nonspecific immune suppression |
| Monocyte-like subset | M1: STAT1, iNOS | M1: High NO, TNFα, Low ROS | Inhibition of MHC class Il expression, T-cell apoptosis |
| M2: STAT 3, Arg-1 | M2: High Arg-1, IL-10, TGFβ | Activation of Treg, induction of T-cell anergy, long-term tolerance |
