Table 2. Proteins reported changed in experimental acute pancreatitis.
| INCREASED – 97 proteins | Reference |
|---|---|
| Inflamatory Response – 36 proteins | |
|
|
|
| Apolipoprotein A1 | 7,9,10 |
| Complement C3 | 7,10 |
| Fibrinogen (α,β, and γ chains) | 9,12 |
| Hemopexin | 9,10 |
| Murinoglobulin | 7,10 |
| Serum albumin | 7,9,10 |
| Response to Stress – 13 proteins | |
|
|
|
| Clusterin | 9,10,11 |
| Hypoxia Upregulated Protein 1 (ORP-150) | 5,6 |
| Pap2 (Reg 3A) | 7,10 |
| Protein Disulfide Isomerase | 5,9 |
| 78 KDa Glucose Regulated Protein (Bip) | 6,9 |
| Metabolism – 13 proteins | |
|
|
|
| Mitochondrial ATP synthase beta chain | 4,9 |
| Cytoskeleton – 7 proteins | |
|
|
|
| Various Tubulins | 4,12 |
| Other – 27 proteins | |
|
|
|
| DECREASED – 55 proteins | |
| Digestive Enzymes and ZG membrane proteins – 21 proteins | |
|
|
|
| Amylase | 9,10,12 |
| Bile salt activated lipase | 9,10,12 |
| Carboxypeptidase B | 9,12 |
| Chymotrypsin B | 10,12 |
| Ribonuclease | 10,12 |
| Triglyceride Lipase, PLRP-1, and PLRP-2 | 9,10,12 |
| Metabolism – 13 proteins | |
|
|
|
| Isocitrate Dehydrogenase | 6,9 |
| Response to Stress – 4 proteins | |
|
|
|
| 78 KDa Glucose Regulated Protein (Bip) | 5,12 |
| Other -17 Proteins | |
|
|
|
| PROTEOLYSIS – 23 proteins | |
| Inflammatory Response – 9 proteins | |
|
|
|
| Complement C3 | 11,12 |
| Response to Stress – 3 proteins | |
|
|
|
| Cytoskeleton – 3 proteins | |
|
|
|
| Translational Response -2 proteins | |
|
|
|
| Other – 6 proteins | |
|
|
The table includes all proteins uniquely identified with a change in amount of greater than 1.5 fold. Individual proteins reported more than once are listed with references. Note that 78 KDa Glucose Regulated Protein is listed in both increased and decreased categories as reported by different studies.