Figure 5.

atg7 deficiency promotes tumor lipid accumulation. (A) Representative electron microscope images of tumors showing lipid droplet accumulation with atg7 deletion at 18 wk after tumor initiation. (Nu) Nucleus; (M) mitochondria; (L) lamellar body; (G) glycogen; (LD) lipid droplet. (B) Representative low-magnification images of Oil red O staining of representative lung lobes (frozen sections) at 18 wk after tumor induction (n = 2 mice for each genotype). (C) Representative high-magnification images of Oil red O staining of tumor tissue at the indicated times (n = 2 mice for each genotype).