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. 2013 Oct;34(10):2261–2270. doi: 10.1016/j.neurobiolaging.2013.03.030

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© 2013 Elsevier Inc.

Open Access under CC BY 3.0 license

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Fig. 3 — Higher no-go to win performance is associated with higher structural integrity of substantia nigra/ventral tegmental area (SN/VTA) and STN. (A) Region-of-interest analysis of the SN/VTA (single-subject, single-slice illustration of the bilateral SN/VTA region of interest (ROI), blue; see Supplementary Fig. 1 also). Scatter plot (in which each dot represents an individual) shows older individuals with higher SN/VTA integrity, indexed by higher magnetization transfer (MT) values, performed better in the no-go to win condition of the task. (B) An independent whole-brain voxel-based analysis of MT maps confirmed the association between higher MT values and no-go to win learning, localizing to a region overlapping with the right SN/VTA and right STN. Displayed on group-averaged MT image, uncorrected threshold p < 0.001.