Table 2.
Effect of TBI on GSH, GSSG Content and GSH/GSSG Ratio
| |
GSH content (nmol g/tissue) |
GSSG content (nmol g/tissue) |
GSH/GSSG ratio (nmol g/tissue) |
|||
|---|---|---|---|---|---|---|
| Treatment | Sham | TBI | Sham | TBI | Sham | TBI |
| NaCI | 34.57±1.50 | 33.22±1.71 | 17.40±1.16 | 16.83±1.01 | 2.05±0.14 | 2.01±0.11 |
| PTZ | 31.14±1.64 | 34.59±2.04 | 15.75±0.64 | 18.30±0.96 | 1.99±0.10 | 1.91±0.10 |
| NaCl/Ex | 36.07±1.85* | 35.42±2.06* | 17.35±0.81 | 14.17±0.73 | 2.10±0.13* | 2.56±0.21* |
| PTZ/Ex | 35.80±1.52* | 37.36±2.07* | 15.68±0.71 | 17.49±0.94 | 2.34±0.18* | 2.18±0.15* |
Data from GSH and GSSG content. Data are mean±standard error of the mean for n=8–11 in each group.
*
p<0.05, comparing physical exercise groups to sedentary animals on increased GSH and GSH/GSSG content, with no significant effect of other factors (three-way analysis of variance and Student-Newman-Keuls SNK tests).
TBI, traumatic brain injury; GSH, reduced glutathione; GSSG, oxidized glutathione; PTZ, pentylenetetrazol; Ex, animals submitted to exercise protocol.