Table 1.
Human RMS cell lines reported and used by multiple research groups.
| Cell lines | Origin | Previous treatment | Karyotype/gene fusion status | STR |
|---|---|---|---|---|
| EMBRYONAL HISTOLOGY | ||||
| CCA | “Vesical” recurrence | Unknown | Multiple chromosomal rearrangements, Q61L mutation of KRAS | Unknown |
| CT-TC | Primary tumor | Unknown | Unknown | Unknown |
| HX170c | Paratesticular tumor of 5-year-old male at recurrence | Yes | Near diploid | Unknown |
| JR-1 | Lung metastasis 7-year-old female | Yes | Near tetraploid, TP53 mutation | Unknown |
| KF-RMS-1 | Bone marrow metastasis | Unknown | Unknown | Unknown |
| RD | Pelvic mass 7-year-old female | Yes | 51-hyperdiploid, MYC amplification, Q61H mutation of NRAS, TP53 mutation | Yes |
| RH6 | Lymph node metastasis 16-year-old male | Unknown | Unknown | Unknown |
| RH12 | Buttock tumor | No | Multiple chromosomal rearrangements | Unknown |
| RH14 | Inguinal tumor at recurrence | Yes | Unknown | Unknown |
| RH36 (Birch) | Paratesticular relapse 15-year-old male | Yes | Unknown | Unknown |
| RMS559/R31 | Unknown | Unknown | V550L mutation of FGFR4 | Unknown |
| RMS-YM | Abdominal mass 2-year-old male | Unknown | Multiple chromosomal rearrangements, upregulation of MDM2, FGFR1 | Unknown |
| RUCH2 | Botryoid vaginal mass 15-month-old female | No | Multiple chromosomal rearrangements | Unknown |
| RUCH3 | Unknown | Unknown | Unknown | Unknown |
| SCMC-RM2 | Bone marrow metastasis of 11-year-old female | Yes | NMYC amplification | |
| SMS-CTR | Pelvic mass 1-year-old | No | Hypertriploid, t(1;13)(q21;q14) and t(2;13)(p25;q14)* | Yes |
| TTC442 | Unknown | Unknown | Unknown | Unknown |
| TTC516 | Unknown | Unknown | Unknown | Unknown |
| ALVEOLAR HISTOLOGY | ||||
| CW9019 | Unknown | Unknown | t(1;13) | Unknown |
| D-RHA1 | Unknown | Unknown | Unknown | Unknown |
| KFR | Bone marrow metastasis | No | Pseudodiploid, t(2;13)(q35;q14)$ | Unknown |
| RH5 | Unknown | No | Unknown | Unknown |
| RH10 | Perineal relapse 5-year-old female | Yes | Hyperdiploid, t(2;13) | Unknown |
| RH18 fusion-negative | Perineal mass 2-year-old | No | Amplification of 12q13–15 region including MDM2 | Yes |
| RH18 fusion-positive | Perineal mass 2-year-old | No | t(2;13) | Yes |
| RH28 (RH3) | Axillary metastasis 17-year-old male | No | Near tetraploid t(2;13) | Yes |
| RH30 (RMS13) | Bone marrow metastasis 16-year-old male | No | t(2;13), TP53 mutation, amplification of 12q13–15 region including CDK4 | Yes |
| RH41 (RH4) | Lung metastasis 7-year-old female | Yes | t(2;13), TP53 mutation | Yes |
| RH65 | Relapse 18-year-old female | Yes | Unknown | Unknown |
| RMZ-RC2 | Bone marrow metastasis 2-year-old | Yes | PAX7-FOXO1, NMYC amplification | Unknown |
| TC212 | Bone marrow metastasis 16-year-old male | Yes | t(2;13)(q35;q14)$ | Unknown |
*These are not the characteristic translocations associated with ARMS. See text.
$There was a time that the 2q breakpoint was assigned to q35 or q37; this has now been resolved as a q35 breakpoint. See text.