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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Drug Metab Lett. 2012 Sep 1;6(3):157–164. doi: 10.2174/1872312811206030002

Table 1.

Kinetic Parameters of R- and S-warfarin Metabolism by Recombinant CYP2C19a

Producta R-warfarin S-warfarin
Vmaxb Km
(μM)		 Vmax/Km
(× 103)c 		Vmaxb Km
(μM)		 Vmax/Km
(× 103)c
6-hydroxywarfarin 0.34
(0.32-0.38)		 20
(12-27)		 17 0.40
(0.34-0.45)		 33
(17-49)		 12
7-hydroxywarfarin 0.55
(0.49-0.60)		 14
(7.2-21)		 39 0.50
(0.47-0.53)		 32
(24-40)		 16
8-hydroxywarfarin 0.21
(0.20-0.22)		 17
(13-21)		 12 0.31
(0.28-0.34)		 17
(9.0-26)		 18
4′-hydroxywarfarin 0.18
(0.16-0.20)		 39
(23-56)		 4.6 0.17
(0.13-0.20)		 83
(31-135)		 2.0
a

95% confidence intervals are shown in parentheses

b

Units are nmol/min/nmole P450

c

Units are per min per μM