Table 2.
Pearson Correlation Values Between R- and S-hydroxywarfarin Formation Rates and P450 Activities as Measured with a Bank of Nine Human Liver Microsomal Samples (See Figs. 3 and 4)a, b
| P450 isoform |
Probe | Drug | 6-Hydroxywarfarin | 7-Hydroxywarfarin | 8-Hydroxywarfarin | 10-Hydroxywarfarin | 4′-Hydroxywarfarin | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R value | P value | R value | P value | R value | P value | R value | P value | R value | P value | |||
| CYP1A2 | PHEN | R-WAR S-WAR |
0.66 0.66 |
0.056 0.054 |
0.67 0.50 |
0.049* 0.17 |
0.45 0.16 |
0.22 0.67 |
0.40 0.063 |
0.29 0.87 |
−0.44 −0.023 |
0.24 0.95 |
| CYP2C19 | MEPH | R-WAR S-WAR |
0.91 0.37 |
0.0006*** 0.32 |
0.82 0.28 |
0.0069** 0.46 |
0.90 −0.045 |
0.0009*** 0.91 |
−0.020 −0.98 |
0.96 0.80 |
−0.50 −0.46 |
0.17 0.22 |
a
PHEN, phenacetin; MEPH, S-mephenytoin; WAR, warfarin
b
Asterisks indicate statistically significant correlations