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. Author manuscript; available in PMC: 2013 Jul 17.
Published in final edited form as: J Immunol. 2012 Mar 7;188(8):4023–4031. doi: 10.4049/jimmunol.1102779

Figure 3. Blocking of IL-4 restores the defect in TH17 differentiation.

Figure 3

(A) Sorted naïve CD4 T cells were activated with plate-bound anti-CD3 and anti-CD28 in the presence of TGF-β, IL-6, IL-1, and IL-23 and blocking antibodies against IL-4 and/or IL-2 as specified. The percentage of IL-17 and IL-4 producers was analyzed using flow cytometry on day 5 of culture. This data is representative of 5 different experiments. (B) Combined data from 5 experiments. Open bars represent Ndfip1+/+ and black bars represent Ndfip1−/− T cells. *** p< 0.005.