Table 1.

Serum parameters, hepatic and urinary bile acids of Ostα ^+/+ and Ostα ^−/− mice.

	Ostα +/+ sham	Ostα −/− sham	Ostα +/+ BDL	Ostα −/− BDL
Serum ALT (U/L)	4.8 ± 1.3	4.8 ± 1.2	56.1 ± 26.6+	31.8 ± 2.2#
Serum γGT (U/L)	7.6 ± 1.7	10.8 ± 5.0	71.6 ± 31.2+	17.8 ± 3.3*
Serum bile acids (μM)	12.5 ± 12.4	11.9 ± 9.0	2023 ± 647+	371 ± 133#*
Serum bilirubin (mg/dL)	0.11 ± 0.11	0.18 ± 0.13	23.1 ± 9.1+	6.1 ± 1.8#*
Hepatic bile acids (μM)	10.5+11.2	ND	130.2+36.3+	68.6+12.0#*
Urinary bile acids (μM)	0	0	132.9 ± 25.5	316.7 ± 104.5*
Urinary bile alcohol sulfates (μM)	BD	BD	57 ± 53	258 ± 242

Data represent mean ± SD of n = 4–6. ALT, aminotransferase; γGT, γ-glutamyl-transpeptidase; BD, below detection limit; ND, Not done

⁺p < 0.001, Ostα^+/+ Sham VS Ostα^+/+ BDL

^#p < 0.001, Ostα^−/− Sham VS Ostα^−/− BDL

^*p < 0.005, Ostα^+/+ BDL VS Ostα^−/− BDL

%p<0.05, Ostα^+/+ Sham VS Ostα^−/− Sham