Fig. 5.

Genes of interest in memory impairment exhibit similar expression profiles in postmortem normal brain tissue. a) Normalized, microarray-based expression profiles across 25 major neuroanatomic regions of the brain are provided for 10 key genes of interest. Moving from left to right on the heat map is analogous to moving from anterior to posterior regions first in the cortex, followed by subcortical areas and then the cerebellum and brainstem. The genes represented exhibit strong co-expression (Pearson r > 0.7) across the brain in data from two subjects. b) For the co-expressed gene set, a representative cortical and subcortical expression profile is shown for the CAMK2A gene.

*Images derived from the Allen Human Brain Atlas.