Table 2.
MR imaging, 1H- and 31P-MRS data for DMD and control groups
| Parameter | DMD group | Control group | P-value | |
|---|---|---|---|---|
| MR imaging | ||||
|
| ||||
| IMAT/mCSA | 0.16 ± 0.09 | 0.08 ± 0.05 | 0.04 | |
|
| ||||
| IMAT (cm2) | 9.36 ± 10.4 | 4.73 ± 3.4 | 0.25 | |
|
| ||||
| mCSA (cm2) | 52.1 ± 26.6 | 61.5 ± 17.3 | 0.41 | |
|
| ||||
| 1H-MRS | ||||
| TA LF (%) | 9.2 ± 12.6 | 2.5 ± 2.0 | 0.02 a | |
| SOL LF (%) | 28.4 ± 24.8 | 7.4 ± 4.0 | 0.003a | |
|
| ||||
| 31P-MRS (anterior lower leg) | ||||
| PCr (AU) | 274.8 ± 74.9 | 332.0 ± 38.2 | 0.07 | |
| Pi (AU) | 74.1 ± 28.2 | 65.9 ± 26.8 | 0.56 | |
| PCr/Pi | 4.2 ± 1.9 | 5.6 ± 1.6 | 0.14 | |
| pH | 7.09 ± 0.03 | 7.03 ± 0.02 | 0.0003 | |
|
| ||||
| 31P-MRS (posterior lower leg) | ||||
| PCr (AU) | 254.9 ± 66.8 | 290.2 ± 21.7 | 0.17 | |
| Pi (AU) | 67.9 ± 18.7 | 59.4 ± 13.5 | 0.30 | |
| PCr/Pi | 3.8 ± 0.8 | 5.1 ± 1.2 | 0.02 | |
| pH | 7.12 ± 0.05 | 7.09 ± 0.03 | 0.13 | |
a
ANCOVA after log conversion to approximate a normal distribution and controlling for unsuppressed water concentration.
IMAT/mCSA, intramuscular adipose tissue normalized to total muscle cross sectional area; LF, lipid fraction; TA, tibialis anterior; SOL, soleus; AU, arbitrary units.