Immunostaining of Wnt2 in placental tissue sections of the 2 groups. Wnt2 immunostaining is mainly localized in the syncytiotrophoblast and the extravillous trophoblast. The immunostaining of Wnt2 were reduced in severe preeclamptic placentas (B and D) compared to the normal placentas (A and C). E and F, Serial sections of C and D stained with HLA-G. STB indicates syncytiotrophoblast; VCTB, villous trophoblast; EVT, extravillous trophoblast. Original magnification 400× for A and B, 200× for C-F. Scale bar = 20 µm for A and B, scale bar = 40 µm for C-F.