Figure 4.

Immunostaining of sFRP4 in placental tissue sections of the 2 groups. Immunoreactivity for sFRP4 was consistently found in the villous syncytiotrophoblast and the extravillous trophoblast. Immunostaining of sFRP4 were more frequently present in severe PE (B and D) versus control placentas (A and C). E and F, Serial sections of C and D stained with HLA-G. STB indicates syncytiotrophoblast; VCTB, villous trophoblast; EVT, extravillous trophoblast; PE, preeclampsia; sFRP4, secreted frizzled-related protein 4. Original magnification 400× for A and B, 200× for C-F. Scale bar = 20 µm for A and B, scale bar = 40 µm for C-F.