Table 1.
CatWalk gait analysis
| Parameter | Paws | Description (units) | Cross-sectional dataa |
6 months | Longitudinal datab |
Interaction | ||
|---|---|---|---|---|---|---|---|---|
| 2 months | 4 months | Group | Time | |||||
| Stand index | Front paws | Speed at which the paw loses contact with the glass plate (arbitrary units) | NS | 4.10* (0.03) | NS | NS | 19.54* (0.0008) | 7.31* (0.01) |
| Hind paws | NS | 2.46* (0.001) | 4.35* (0.002) | 30.75* (0.005) | 31.35* (0.0002) | 25.47* (0.0003) | ||
| Swing | Front paws | Duration of no contact of the paw with the glass plate (seconds) | NS | NS | 0.07* (0.03) | NS | 8.23* (0.01) | NS |
| Hind paws | 0.06* (0.0003) | NS | 0.07* (0.01) | NS | 19.81* (0.0008) | 10.35* (0.006) | ||
| Step cycle | Front paws | Time between two consecutive initial contacts of the same paw (seconds) | NS | NS | 0.14* (0.01) | NS | NS | NS |
| Hind paws | NS | NS | 0.14* (0.004) | NS | NS | NS | ||
| Cadence | Steps per second | NS | NS | 4.30* (0.005) | 25.26* (0.007) | NS | NS | |
| Print area | Front paws | Surface area of the complete paw print (mm2) | NS | NS | NS | NS | NS | NS |
| Hind paws | NS | 3.84* (0.006) | 4.49* (0.01) | NS | 181.00* (<0.0001) | 4.90* (0.04) | ||
| Support single | Percentage of time one paw is in contact with the glass plate | NS | NS | 2.57* (0.02) | NS | NS | NS | |
| Support diagonal | Diagonal paws | Percentage of time diagonal paws are in contact with the glass plate | NS | NS | NS | 11.30* (0.02) | 14.11* (0.002) | NS |
| Support girdle | Front versus hind paws | Percentage of time girdle paws are in contact with the glass plate | NS | NS | NS | NS | NS | NS |
| Support lateral | Left versus right paws | Percentage of time lateral paws are in contact with the glass plate | NS | NS | NS | NS | NS | NS |
| Support three | Percentage of time three paws are in contact with the glass plate | NS | NS | 10.18* (0.003) | 12.41* (0.02) | 20.35* (0.0007) | NS | |
| Support four | Percentage of time all four paws are in contact with the glass plate | NS | NS | NS | NS | NS | NS | |
| Base of support | Front paws | Distance between girdle paws (mm) | NS | NS | NS | NS | 14.54* (0.002) | NS |
| Hind paws | NS | NS | NS | 31.45* (0.005) | 51.36* (<0.0001) | NS | ||
N = 7 for each group (wild-type and Plp1dup) at each time (2, 4, and 6 months). NS, Not significant.
*Significant (p < 0.05).
aCross-sectional data comparing groups at each time point (t test) are presented as difference between means (p value).
bLongitudinal data (two-way repeated measures ANOVA) are presented as F (p value). Interaction is of group and time.