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. 2013 Jul 17;33(29):11825–11832. doi: 10.1523/JNEUROSCI.3317-12.2013

Figure 6.

Figure 6.

Selective enhancement of mGluR-dependent LTD after fear conditioning. A, Mice received six pairings of tone (CS) and footshock (US) 24 h before slice preparation. In the control condition, CS and US were explicitly unpaired. B–D, Comparison of LFS LTD (B), ppLFS LTD (C), and (RS)-3,5-dihydroxyphenylglycine LTD (D; 50 μm bath application) in mice receiving unpaired versus paired fear conditioning. Calibration: B, unpaired, 120 pA, 20 ms; paired, 80 pA, 20 ms; C, unpaired, 80 pA, 20 ms; paired, 150 pA, 20 ms; D, unpaired, 200 pA, 20 ms; paired, 150 pA, 20 ms. Example traces are sampled from the shaded regions. All data points represent group means ± SE.