Figure 3.

Snapshots of three different relative orientations of IgG1 on the PS surface obtained from the docking simulation.

Notes: The orientations of Fab-Fab-on (A), Fc-on (B), and Fab-Fc-on (C) are shown in the top row. Schematic representations are shown in the insets of the top row. The interacting regions between IgG1 and the PS surface are indicated in the figures from (a) to (e). The interacting amino acid residues are shown by vdW representations with yellow color. Interacting chains in each of the three orientations were extracted and shown in the bottom row, where the interacting amino residues with the PS surface are again represented by vdW spheres with yellow color. Equivalent amino residues in the other pair chains of IgG1 are shown in the same figure by vdW spheres with green and blue colors.

Abbreviations: IgG1, immunoglobulin G1; PS, polystyrene; H, heavy chain; L, light chain; C, constant domain; V, variable; vdW, van der Waals interaction; ter, terminal.