Table 3.
Amino acid residues and their interaction energies of IgG1 with the PS surface for Fc–on
| Residues | c-region
|
||
|---|---|---|---|
| vdW | Elec | Total | |
| Uncharged hydrophilic amino acids | |||
| Asn272 | −6.7 | 0.7 | −6.0 |
| Asn306 | −0.7 | −1.8 | −2.5 |
| Charged amino acids | |||
| Asp271 | −4.0 | −12.7 | −16.7 |
| Asp303 | −0.1 | −6.3 | −6.4 |
| Glu309 | −4.6 | −12.1 | −16.7 |
| Glu324 | −1.9 | −7.7 | −9.6 |
| Glu274 | −0.3 | −2.8 | −3.1 |
| Total | −18.3 | −42.7 | −61.0 |
Note: The energies were shown in kcal/mol.
Abbreviations: IgG1, immunoglobulin G1; PS, polystyrene; Fc, fragment crystallizable; vdW, van der Waals interaction; elec, electrostatic; Asn, asparagine; Asp, aspartic acid; Glu, glutamic acid; kcal/mol, kilocalorie per mole.