Table 2.

Spearman rank correlation (ρ) between query log reaction score (QLRS) and the number of adverse drug reaction (ADR) reports in the Adverse Event Reporting System (AERS), with the most discordant ADRs (MDADRs) removed.

Drug	ρ1	P value a	MDADRsb
Advair	0.28		Anxiety, apnea,c chest pain, cough, weight gainc
Aranesp	0.30		Asthenia, back ache, back pain, edemac
Diovan	0.34		Chest pain, cramp,c sleepy,c wound
Effexor	0.54	<.001	Nausea, phobia,c sleepy,c weight gainc
Enbrel	0.39	.02	Back pain, cough, diarrhea, fever, weight gainc
Lipitor	0.54	<.001	Asthenia, constipation, diarrhea, dizziness, nausea
Mabthera	0.38	.01	Chest pain, fever, headache, malaise, woundc
Nexium	0.45	.008	Abdominal pain, tired,c weak,c weight gainc
Norvasc	0.34		Apnea,c constipation, cramp,c tired,c weight lossc
Pantoloc	0.49	.001	Chest pain, fever, headache, malaise, nausea
Pantozol	0.51	.006	Chest pain, fever, headache, malaise, nausea
Plavix	0.25		Back pain, chest pain, cough, paresthesia
Protonix	0.25		Abdominal pain, diarrhea, nausea, vomitc
Remicade	0.37	.04	Chest pain, fever, infertility,c paresthesia, rash
Risperdal	0.40	.02	Diarrhea, headache, insomnia, weight gainc
Rituxan	0.23		Abdominal pain, diarrhea, paresthesia, weakc
Seretide	0.41	0.004	Chest pain, dyspnea,c headache, malaise, nausea
Seroquel	0.48	0.004	Apnea,c dizziness, headache, weight gainc
Singulair	–0.06		Apnea,c dizziness, insomnia, tiredc
Zyprexa	0.61	0.002	Constipation, diarrhea, nausea, paresthesia, somnolence

^a P values are provided for statistically significant correlations (n=45).

^bUnless otherwise indicated, MDADRs are those prominent in AERS.

^cMDADRs emphasized in QLRS.