Table. Details for samples used in a study of the amplification of multidrug-resistant tuberculosis, resulting from competitive growth advantage, during treatment of a drug-sensitive Mycobacterium tuberculosis strain in a mixed infection*.
Sample |
Isolate |
Smear |
Resistance |
MIRU-VNTR |
Bronchoalveolar lavage, obtained February 2008 | S | + | None | 3243323125153242244235-1 |
Sputum, obtained April 2008 | S | ++ | None | 3243323125153242244235-1 |
Sputum, obtained June 2008 | R | +++ | INH, ETB | -2434233251533445-443330 |
Co-cultures 1) broth culture + INH, 2) colonies from broth culture − INH on plate with INH, 3) colonies from broth culture + INH on plates − INH and 4) colonies from broth culture + INH on plates − INH | R | NA | INH | -2434233251533445-443330 |
Co-cultures 5) broth culture − INH and 6) colonies from broth culture − INH on plates − INH | S | NA | NA | 3243323125153242244235-1 |
*MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat; S, drug sensitive; +, ++, and +++, relative burden of acid-fast bacilli; R, drug resistant; INH, isoniazid; ETB, ethambutol; NA, not applicable.