Table 1.
Five disorder meta-analysis results for regions with p<5×10−8
| Chromosome | Base-pair position* |
Nearest gene | Alleles | Frequency† | Imputation quality score (INFO) |
p value | OR (95% CI)‡ | Heterogeneity p value |
Best-fit model (BIC)§ |
|
|---|---|---|---|---|---|---|---|---|---|---|
| rs2535629 | 3 | 52808259 | ITIH3 (+ many) | G/A | 0·651 | 0·942 | 2·54×10−12 | 1·10 (1·07–1·12) | 0·27 | Five disorder¶ |
| rs11191454 | 10 | 104649994 | AS3MT (+ many) | A/G | 0·910 | 1·01 | 1·39×10−8 | 1·13 (1·08–1·18) | 0·32 | Five disorder¶ |
| rs1024582 | 12 | 2272507 | CACNA1C | A/G | 0·337 | 0·98 | 1·87×10−8 | 1·07 (1·05–1·10) | 0·0057 | BPD, schizophrenia |
| rs2799573 | 10 | 18641934 | CACNB2 | T/C | 0·715 | 0·825 | 4·29×10−8 | 1·08 (1·05–1·12) | 0·57 | Five disorder¶ |
Most strongly associated single-nucleotide polymorphisms (SNP) in associated region after clumping—ie, grouping SNPs within 250 kb of the index SNP that have r2>0·2 with the index SNP as implemented in PLINK. OR=odds ratio. BIC=Bayesian information criteria. BPD=bipolar disorder.
*
Detected with University of California Santa Cruz Genome Browser (version hg18).
†
Risk allele frequency in controls.
‡
Estimated OR from multinomial logistic regression used in the modelling analysis.
§
Best-fit multinomial logistic model by BIC criteria; appendix pp 38–45 provide a comparison of BIC and Akaike information criteria across models.
¶
Best-fit model supports an effect on all five disorders.