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. Author manuscript; available in PMC: 2013 Jul 17.
Published in final edited form as: Chem Biodivers. 2011 Sep;8(9):1571–1615. doi: 10.1002/cbdv.201100033

Fig. 27. Differential base stacking at the cross-linking region explains the difference in stabilities of the trimethylene-N2-dG:N2-dG interstrand cross-links in the 5′-CpG-3′ vs. the 5′-GpC-3′ sequences, and, in turn, accounts for the same sequence selectivity of interstrand cross-link formation induced by the enal-derived 1,N2-dG adducts.

Fig. 27

a) and b) show base stacking in the 5′-CpG-3′ sequence; c) and d) show base stacking in the 5′-GpC-3′ sequence. This illustration was prepared from PDB entries 2KNK and 2KNL using PyMol software [39] (© 2009 American Chemical Society).