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. Author manuscript; available in PMC: 2013 Jul 17.
Published in final edited form as: N Engl J Med. 2012 Oct 4;367(14):1310–1320. doi: 10.1056/NEJMoa1107477

Figure 2. Changes in the C-Index with the Addition of Information on C-Reactive Protein or Fibrinogen to a Model with Conventional Risk Factors, According to Subgroup.

Figure 2

P values are for differences in the C-index changes across subgroups. Error bars indicate 95% confidence intervals. For each comparison, only studies with information on all subgroup levels were used (hence, subgroup total numbers do not always equal overall total numbers). Since not all the contributing studies had complete information across all subgroup levels, comparisons across subgroups (e.g., men vs. smokers) may not be reliable owing to between-study differences. “Predicted 10-year CVD risk” refers to the predicted 10-year risk of cardiovascular disease events calculated on the basis of the 2008 version of the Framingham risk score.