Table 1.

Baseline Characteristics and Hazard Ratios for First-Onset Cardiovascular Disease.^*

Characteristic	Participants with Assessment of C-Reactive Protein (N = 166,596)	Hazard Ratio (95% CI)†	Participants with Assessment of Fibrinogen (N = 185,892)	Hazard Ratio (95% CI)†
Mean age at time of survey — yr	59.7±8.6	1.90 (1.86–1.94)	59.3±8.4	1.81 (1.77–1.85)
Male sex — no. (%)	82,077 (49)	NA‡	100,530 (54)	NA‡
Current smoker — no. (%)	35,779 (21)	1.64 (1.58–1.71)	46,799 (25)	1.71 (1.64–1.78)
Systolic blood pressure — mm Hg	136±19	1.26 (1.24–1.28)	137±18	1.30 (1.28–1.32)
History of diabetes — no. (%)	10,802 (6)	1.74 (1.64–1.85)	11,287 (6)	1.89 (1.79–2.00)
Total cholesterol — mmol/liter	5.86±1.06	1.17 (1.15–1.19)	5.80±1.08	1.19 (1.17–1.21)
HDL cholesterol — mmol/liter	1.32±0.38	0.86 (0.84–0.88)	1.32±0.39	0.85 (0.83–0.87)
Loge CRP — mg/liter	0.59±1.09	1.20 (1.18–1.22)	—	—
Fibrinogen — g/liter	—	—	3.15±0.74	1.15 (1.13–1.17)

^*Plus–minus values are means ±SD. Data on C-reactive protein are from 38 studies in which 13,568 participants had a first-ever cardiovascular disease outcome during follow-up, and data on fibrinogen are from 40 studies in which 12,021 participants had a first-ever cardiovascular disease outcome during follow-up. Dashes indicate that summary statistics are not applicable for either CRP or fibrinogen because the models used were based on two separate sets of data to maximize the information on each marker. CRP denotes C-reactive protein.

^†The hazard ratios were calculated per 1-SD increment in the measured level or as compared with the relevant reference category. Where appropriate, hazard ratios were adjusted for age, sex, smoking status, systolic blood pressure, diabetes status, and levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, and C-reactive protein or fibrinogen.

^‡Hazard ratios according to sex are not available (NA) because these models were stratified by sex.