Table 2.

Changes in the C-Index after the Addition of Information on Biomarkers of Inflammation to a Model Including Conventional Risk Factors.^*

Data Source and Risk Factor	Change in C-Index after Addition of Biomarker (95% CI)	P Value for Comparison with Model Including Conventional Risk Factors	P Value for Comparison with Reference
25 Studies with 95,733 participants, 6609 with CVD
Conventional risk factors plus loge CRP	0.0035 (0.0018–0.0051)	<0.001	Reference
Conventional risk factors plus fibrinogen	0.0022 (0.0010–0.0035)	<0.001	0.13
Conventional risk factors plus loge CRP and fibrinogen	0.0040 (0.0023–0.0057)	<0.001	0.10†
10 Studies with 32,160 participants, 3498 with CVD
Conventional risk factors plus loge CRP	0.0031 (0.0010–0.0053)	0.004	Reference
Conventional risk factors plus loge leukocyte count	0.0028 (0.0011–0.0045)	0.002	0.78
17 Studies with 61,002 participants, 8646 with CVD
Conventional risk factors plus loge CRP	0.0038 (0.0023–0.0053)	<0.001	Reference
Conventional risk factors plus albumin	0.0022 (0.0014–0.0030)	<0.001	0.05
15 Studies with 46,699 participants, 5227 with CVD
Conventional risk factors plus fibrinogen	0.0037 (0.0020–0.0053)	<0.001	Reference
Conventional risk factors plus loge leukocyte count	0.0036 (0.0022–0.0051)	<0.001	0.97
16 Studies with 62,502 participants, 6476 with CVD
Conventional risk factors plus fibrinogen	0.0034 (0.0020–0.0048)	<0.001	Reference
Conventional risk factors plus albumin	0.0032 (0.0019–0.0044)	<0.001	0.79

^*Conventional risk factors include age, systolic blood pressure, smoking status, diabetes status, and levels of total and HDL cholesterol. “Reference” refers to the comparator model. CRP denotes C-reactive protein, and CVD cardiovascular disease.

^†P = 0.003 for the comparison of the addition of log_e CRP to a model with fibrinogen.