Table 1.
Patient demographic characteristics, histopathological tumor diagnosis, and treatment details
| Age (years) | Gender | Tumor type | Grade | Type of surgery | Treatment (within scan window) | Scan interval (weeks)1 | Volume change (at 6 months) | New lesions (at 6 months) | RANO response (at 6 months) | Clinical course after end of therapy |
|---|---|---|---|---|---|---|---|---|---|---|
| 10.7 | F | Secr. Germ Cell Tumor | none | Chemotherapy/RT | 2.4 | decrease | N | PR | No Relapse | |
| 2.7 | F | PNET | IV | biopsied | Chemotherapy (COG 921) | 15.1 | no change | N | PD | Death |
| 11.7 | M | Pineoblastoma | IV | biopsied | Chemotherapy (PNET3) | 4.0 | decrease | N | PR | No Relapse |
| 8 | M | Pineal PNET | III | biopsied | Chemotherapy (PNET3) | 6.9 | decrease | N | PR | No Relapse |
| 15 | M | Germinoma | III | biopsied | Radiotherapy | 6.4 | decrease | N | CR | No Relapse |
| 15.8 | F | Glioneuronal tumour | IV | debulking | Chemotherapy (Milan) | 9.7 | decrease | N | SD | Residual Thalamic tumour |
| 4.6 | F | DIPG(GBM) | IV | biopsied | Chemotherapy/RT (TMZ) | 10.0 | no change | N | PD | Death |
| 7.8 | F | DIPG(GBM) | IV | biopsied | Chemotherapy/RT (TMZ) | 16.7 | increase | N | PD | Death |
| 3.5 | F | MB | IV | debulking | Chemotherapy (Milan) | 4.3 | decrease | N | CR | Leptomeningeal spread |
| 1.9 | M | MB | IV | biopsied | Chemotherapy (PNET3) | 4.1 | decrease | N | PR | Death |
| 6.2 | M | DIPG (Glioblastoma) | III | biopsied | Chemotherapy/RT (TMZ) | 13.1 | increase | N | PD | Death |
| 4.7 | M | MB | IV | debulking | Chemotherapy/RT (POG 9031) | 3.4 | decrease | Y | PR | Supra tentorial recurrent tumour |
| 9.2 | M | MB | IV | debulking | Chemotherapy (Milan) | 1.9 | decrease | N | CR | No Relapse |
| 12.3 | M | Germinoma | III | biopsied | Chemotherapy | 2.1 | decrease | N | PR | No Relapse |
| 12.4 | M | GBM | IV | debulking | Chemotherapy/RT (TMZ) | 16.9 | decrease | N | PR | Death |
| 6.8 | M | MB | IV | biopsied | Chemotherapy/RT (POG 9031) | 10.0 | decrease | N | PR | No Relapse |
| 20.6 | M | Glioblastoma(GBM) | IV | biopsied | Chemotherapy (TMZ) | 12.6 | decrease | N | SD | No Relapse |
| 12.8 | F | MB | IV | debulking | Chemotherapy (Milan) | 11.3 | decrease | N | PR | No Relapse |
| 11.2 | F | Pineoblastoma | IV | biopsied | Chemotherapy (PNET3) | 8.9 | decrease | N | PR | No Relapse |
Abbreviations: COG, Children's Oncology Group; CR, complete response; DIPG, diffuse intrinsic pontine glioma; GBM, glioblastoma multiforme; MB, medulloblastoma; PD, progressive; PNET, primitive neuroectodermal tumor; POG, Pediatric Oncology Group; PR, partial response; RANO, Response Assessment in Neuro-Oncology; RT, radiotherapy; SD, stable disease; TMZ, tomozolomide.