Table 2.
Differences between responders and nonresponders in patient demographic characteristics and regional diffusion candidate biomarkers.
| Variable | Responders mean ± SD, or mean [range] | non-responders mean ± SD, or mean [range] | P | η2 |
|---|---|---|---|---|
| Age (years) | 9.1 (±4.1) | 9.6 (±7.0) | NS | – |
| Scan time (weeks after treatment) | 6.4 [1.0–16.2] | 6.9 [2.4–12.3] | NS | – |
| Volume decrease (%) | 33 (±35) | 25 (±21) | NS | – |
| Baseline ADC (×10−3mm2/s) | 1.0 (±0.2) | 1.1 (±0.2) | NS | – |
| Baseline nADC | 1.2 (±0.2) | 1.5 (±0.2) | NS | – |
| ADCr (% increase) | 30 (±27) | 2 (±19) | 0.08 | – |
| nADCr (% increase) | 35 (±23) | 3 (±16) | 0.03 | 0.38 |
Significance and effect size (for significant candidate biomarkers only). Abbreviations: ADCr, ADC ratio; η2, partial eta squared if significant; nADC, normalized ADC; nADCr, normalized ADC ratio; NS, not significant.