Table 6.
Characteristics of Patients on the UNOS Lung Transplantation Waiting List for the Initial Two Years of the Pre-Lung Allocation Score and Lung Allocation Score Cohorts, by Gender a
|
Pre-LAS (n=2669) |
LAS (n=2650) |
|||||||
|---|---|---|---|---|---|---|---|---|
|
Male (n, %) |
Female (n, %) |
p value |
Male (n, %) |
Female (n, %) |
p value |
|||
| Characteristics | (n=1338) | (n=1331) | (n=1436) | (n=1214) | ||||
| Age (mean, SD) | 49.7 (12.2) | 48.1 (12.2) | 0.001 | 53.7 (12.3) | 50.6 (13.3) | <0.001 | ||
| African American | 90 (6.7) | 172 (12.9) | <0.001 | 116 (8.1) | 146 (12.0) | <0.001 | ||
| Body Mass Index, kg/m2 (mean, SD) |
25.0 (4.9) | 23.9 (5.1) | <0.001 | 25.5 (4.5) | 24.1 (4.8) | <0.001 | ||
| (n=1316) | (n=1300) | (n=1407) | (n=1204) | |||||
| Diabetes mellitus | 144 (10.9) | 128 (9.9) | 0.36 | 242 (17.2) | 178 (14.8) | 0.09 | ||
| (n=1338) | (n=1331) | (n=1436) | (n=1214) | |||||
| Total serum albumin g/dL (mean, SD) |
3.96 (0.59) | 3.86 (0.58) | <0.001 | 3.94 (0.69) | 3.94 (0.68) | 0.60 | ||
| Performance Status | ||||||||
| (n=1244) | (n=1214) | (n=1142) | (n=1006) | |||||
| 6-Min Walk Distance <150 ft |
104 (8.4) | 108 (8.9) | 0.64 | 152 (13.3) | 120 (11.9) | 0.34 | ||
| (n=1247) | (n=1230) | (n=1412) | (n=1186) | |||||
| Poor Performance Status, Registration |
730 (58.5) | 749 (60.9) | 0.23 | 393 (27.8) | 303 (25.6) | 0.19 | ||
| Blood Group | (n=1338) | (n=1331) | (n=1436) | (n=1214) | ||||
| A | 516 (38.6) | 504 (37.9) |  |
591 (41.2) | 510 (42.0) |  |
||
| AB | 46 (3.4) | 67 (5.0) | 0.09 | 56 (3.9) | 57 (4.7) | 0.13 | ||
| B | 138 (10.3) | 158 (11.9) | 168 (11.7) | 110 (9.1) | ||||
| O | 638 (47.7) | 602 (45.2) | 621 (43.3) | 537 (44.2) | ||||
| Education Level | (n=1338) | (n=1331) | (n=1436) | (n=1214) | ||||
| No education or Grade School |
34 (2.5) | 36 (2.7) |  |
32 (2.2) | 15 (1.2) |  |
||
| High School or Some College |
788 (58.9) | 841 (63.2) | 0.02 | 834 (58.1) | 750 (61.8) | 0.03 | ||
| College Degree or Graduate Degree |
301 (22.5) | 236 (17.7) | 324 (22.6) | 276 (22.7) | ||||
| Unknown or Unavailable |
215 (16.1) | 218 (16.4) |
246 (17.1) | 173 (14.3) | ||||
| Regionb | (n=1338) | (n=1331) | (n=1436) | (n=1214) | ||||
| Northeast | 305 (22.8) | 283 (21.3) |  |
300 (20.9) | 275 (22.7) |  |
||
| Southeast | 414 (30.9) | 418 (31.4) | 0.47 | 467 (32.5) | 360 (29.7) | 0.40 | ||
| Midwest | 457 (34.2) | 445 (33.4) | 421 (29.3) | 359 (29.6) | ||||
| West | 162 (12.1) | 185 (13.9) | 248 (17.3) | 220 (18.1) | ||||
| Pre-LAS (n=2669) |
LAS (n=2650) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Male | Female | p value |
Male | Female | p value |
|||
|
Thoracic Diagnosis Groupc |
(n=1326) | (n=1315) | (n=1436) | (n=1214) | ||||
| A | 616 (46.5) | 726 (55.2) |  |
516 (35.9) | 531 (43.7) |  |
||
| B | 47 (3.5) | 126 (9.6) | <0.001 | 33 (2.3) | 86 (7.1) | <0.001 | ||
| C | 211 (15.9) | 186 (14.1) | 183 (12.7) | 175 (14.4) | ||||
| D | 452 (34.1) | 277 (21.1) | 704 (49.0) | 422 (34.8) | ||||
|
Insurance Provider |
(n=1338) | (n=1331) | (n=1436) | (n=1214) | ||||
| Medicare | 240 (17.9) | 255 (19.2) |  |
396 (27.6) | 304 (25.0) |  |
||
| Medicaid | 81 (6.1) | 115 (8.6) | <0.001 | 82 (5.7) | 88 (7.3) | 0.001 | ||
| Private/ Self | 919 (68.7) | 905 (68.0) | 890 (62.0) | 794 (65.4) | ||||
| Other | 98 (7.3) | 56 (4.2) | 68 (4.7) | 28 (2.3) | ||||
|
Median Income, Dollars (IQR) |
(n=1300) 50358 |
(n=1294) 50950 |
0.76 |
(n=1394) 49827 |
(n=1183) 49849 |
0.87 | ||
| (22333) | (21320) | (21307) | (22416) | |||||
|
Waiting Time While Listed (Days) |
||||||||
| (n=832) | (n=766) | (n=1214) | (n=904) | |||||
| To Transplant (Median, IQR) |
255 (471) | 350 (485) | 0. 001 | 56 (130) | 100 (231) | <0.001 | ||
| (n=368) | (n=384) | (n=154) | (n=174) | |||||
| To Removal for Death/ Too Sick (Median, IQR) |
260 (381) | 276 (470) | 0. 47 | 50 (171) | 241 (438) | <0.001 | ||
| Removal Coded | (n=1338) | (n=1331) | (n=1436) | (n=1214) | ||||
| Still waiting | 0 (0) | 0 (0) |  |
0 (0) | 0 (0) |  |
||
| Transplanted | 832 (62.2) | 766 (57.6) | 1214 (84.5) | 904 (74.5) | ||||
| Too sick for Lung Transplant |
28 (2.1) | 26 (2.0) | 0.03 | 36 (2.5) | 45 (3.7) | <0.001 | ||
| Died | 606 (25.2) | 92 (35.1) | 118 (8.2) | 129 (10.6) | ||||
| Other | 138 (10.3) | 181 (13.6) | 68 (4.7) | 136 (11.2) | ||||
| Status at Removale | (n=1200) | (n=1150) | (n=1368) | (n=1078) | ||||
| Transplanted | 832 (69.3) | 766 (66.6) |  |
0.16 | 1214 (88.7) | 904 (83.9) |  |
<0.001 |
| Died or Too Sick for Lung Transplant |
368 (30.7) | 384 (33.4) | 154 (11.3) | 174 (16.1) | ||||
Abbreviations: UNOS – United Network for Organ Sharing; LAS – lung allocation score.
Pre-LAS cohort was between January 1, 2000 and December 31, 2001, and LAS cohort was between May 4, 2005 and May 3, 2007.
Northeast includes UNOS regions 1, 2, and 9; southeast includes UNOS regions 3, 4, and 11; midwest includes UNOS regions 7, 8, and 10; and west includes UNOS regions 5 and 6.
Thoracic diagnostic group A includes candidates with obstructive lung diseases; group B includes candidates with pulmonary vascular disease; group C includes candidates with cystic fibrosis and immunodeficiency disorders; and group D includes candidates with restrictive lung diseases.
Removal code refers to patients who are removed from the waiting list for reasons such as lung transplantation, too sick for transplantation, death, or other reasons (condition improved, refused transplant, transferred to or transplanted at another center, or living donor transplant).
Status at removal refers to patients who were either (a) transplanted, or (b) died or were deemed too sick for lung transplantation.