Table 3. Selected carbohydrate-active gene modules detected in the fungus-cultivating termite gut metagenome.

CAZy family*	Known CAZy Activities§	Reads in O. yunnanensis
	Cellulases and endohemicellulases
GH5	Cellulase, β-mannnanse, β-1,3-glucosidase, β-1,4-endoxylanase, others	67
GH8	Cellulase, endo-1,4-β-xylanase, chitosanase, others	7
GH9	Endoglucanase, cellobiohydrolase, β-glucosidase	59
GH10	Xylanase, β-1,3-endoxylanase	29
GH26	β-1,3-Xylanase, mannanase	14
GH74	Endoglucanase; oligoxyloglucan reducing end cellobiohydrolase; xyloglucanase	23
GH113	β-mannanase	2
GH124	Endoglucanase	4
Total		205 (2.8%)
	Debranching enzymes and Oligosaccharide degrading enzymes
GH1	β-Glucosidase, β-galactosidase, β-mannosidase	59
GH2	β-Galactosidase, β-mannosidase, β-glucuronidase	742
GH3	β-Glucosidase, β-xylosidase, α-L-arabinofuranosidase, others	183
GH4	α-Glucosidase, α-galactosidase, α-glucuronidase	35
GH27	α-Galactosidase	10
GH29	α-L-fucosidase	145
GH30	Glucosylceramidase, β-1,6-glucanase, β-xylosidase, β-glucosidase	67
GH31	α-Glucosidase, α-xylosidase	122
GH35	β-Galactosidase	20
GH36	α-Galactosidase	135
GH39	β-Xylosidase, α-L-iduronidase	23
GH42	β-Galactosidase	54
GH43	Xylanase, β-xylosidase, α-Larabinofuranosidase, arabinanase	282
GH51	Endoglucanase, α-L-arabinofuranosidase	127
GH53	β-1,4-endogalactanase	5
GH67	α-Glucuronidase	36
GH78	α-L-rhamnosidase	225
GH93	Exo-1,5-α-L-arabinanase	9
GH94	Cellobiose phosphorylase, chitobiose phosphorylase	60
GH97	α-Glucosidase, α-galactosidase	162
GH106	α-L-Rhamnosidase	161
GH115	Xylan α-1,2-glucuronidase, α-(4-O-methyl)-glucuronidase	31
GH116	Acid β-glucosidase, β-glucosidase, β-xylosidase	3
GH120	β-Xylosidase	2
GH121	β-L-arabinobiosidase	5
GH127	β-L-arabinofuranosidase	143
CE1	Acetyl xylan esterase, feruloyl esterase, carboxylesterase	223
CE2	Acetyl xylan esterase	6
CE3	Acetyl xylan esterase	26
CE5	Acetyl xylan esterase; cutinase	1
CE6	Acetyl xylan esterase	17
CE7	Acetyl xylan esterase, cephalosporin-C deacetylase	58
Total		3177 (43.9%)
	Fungal cell wall degrading enzymes
GH18	Chitinase, endo-b-N-acetylglucosaminidase, non-catalytic proteins	54
GH19	Chitinase	6
GH20	β-Hexosaminidase, lacto-N-biosidase	186
GH38	α-Mannosidase, mannosyl-oligosaccharide α-1,3-1,6-mannosidase and α-1,3-mannosidase	30
GH55	Exo-1,3-glucanase, endo-1,3-glucanase	43
GH76	α-1,6-Mannanase	22
GH81	Endo-β-1,3-glucanase	7
GH85	Endo-β-N-acetylglucosaminidase	2
GH92	Mannosyl-oligosaccharide α-1,2-mannosidase; α-1,3-mannosidase and α-1,6-mannosidase; α-1,2-mannosidase; α-1,3-mannosidase, others	427
GH99	Glycoprotein endo-α-1,2-mannosidase	19
GH125	Exo-α-1,6-mannosidase	56
GH128	β-1,3-glucanase	1
CE4	Chitin, chitooligosaccharide, peptidoglycan GlcNAc and MurNAc deacetylase	81
Total		934 (12.9%)

^*The carbohydrate-active enzymes database (CAZy), http://www.CAZy.org.

^§Known CAZy activities were given according to the CAZy database.

^†Carbohydrate-active enzymes were detected with the set of CAZy family-specific HMMs defined by Yin et al [24], as deposited on dbCAN (http://csbl.bmb.uga.edu/dbCAN/), in the BLAST searches (E≤10⁻⁴). All identified CAZymes were listed in Table S2. Besides, searches for GHs-associated domains were also performed and indexed in Table S3.