Table 1. Incidence rate ratio (IRR) of stroke in individuals receiving antiviral treatment for herpes zoster by time since treatment compared with individuals with no history of antiviral treatment in Danish adults 1995–2008.
Time since herpes zoster treatment | ||||||||||||
<14 days | 14 days –1 year | >1 year | ||||||||||
Years* | Cases | IRR (CI)¤ | p-value# | Years* | Cases | IRR (CI)¤ | p-value# | Years* | Cases | IRR (CI)¤ | p-value# | |
Overall | 5 | 83 | 2.27 (1.83–2.82) | 100 | 931 | 1.17 (1.09–1.24) | 413 | 3862 | 1.05 (1.02–1.09) | |||
Sex | 0.71 | 0.72 | 0.49 | |||||||||
Men | 2 | 37 | 2.38 (1.72–3.29) | 40 | 401 | 1.18 (1.07–1.30) | 166 | 1613 | 1.04 (0.99–1.09) | |||
Women | 3 | 46 | 2.19 (1.64–2.92) | 60 | 530 | 1.15 (1.06–1.26) | 247 | 2249 | 1.06 (1.02–1.11) | |||
Age at time of herpes zoster treatment | 0.08 | 0.0002 | 0.002 | |||||||||
<40 years | 1 | 2 | 5.52 (1.38–22.1) | 21 | 22 | 2.71 (1.79–4.12) | 94 | 68 | 1.27 (1.00–1.61) | |||
40–59 years | 2 | 14 | 3.77 (2.23–6.37) | 30 | 118 | 1.40 (1.16–1.67) | 137 | 651 | 1.18 (1.09–1.28) | |||
≥60 years | 2 | 67 | 2.06 (1.62–2.62) | 49 | 791 | 1.12 (1.05–1.20) | 182 | 3143 | 1.03 (0.99–1.06) |
Person years in thousands.
Adjusted for age, sex, and calendar period.
Test for homogeneity.