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. 2013 Jul 17;8(7):e69156. doi: 10.1371/journal.pone.0069156

Table 1. Incidence rate ratio (IRR) of stroke in individuals receiving antiviral treatment for herpes zoster by time since treatment compared with individuals with no history of antiviral treatment in Danish adults 1995–2008.

Time since herpes zoster treatment
<14 days 14 days –1 year >1 year
Years* Cases IRR (CI)¤ p-value# Years* Cases IRR (CI)¤ p-value# Years* Cases IRR (CI)¤ p-value#
Overall 5 83 2.27 (1.83–2.82) 100 931 1.17 (1.09–1.24) 413 3862 1.05 (1.02–1.09)
Sex 0.71 0.72 0.49
Men 2 37 2.38 (1.72–3.29) 40 401 1.18 (1.07–1.30) 166 1613 1.04 (0.99–1.09)
Women 3 46 2.19 (1.64–2.92) 60 530 1.15 (1.06–1.26) 247 2249 1.06 (1.02–1.11)
Age at time of herpes zoster treatment 0.08 0.0002 0.002
<40 years 1 2 5.52 (1.38–22.1) 21 22 2.71 (1.79–4.12) 94 68 1.27 (1.00–1.61)
40–59 years 2 14 3.77 (2.23–6.37) 30 118 1.40 (1.16–1.67) 137 651 1.18 (1.09–1.28)
≥60 years 2 67 2.06 (1.62–2.62) 49 791 1.12 (1.05–1.20) 182 3143 1.03 (0.99–1.06)
*

Person years in thousands.

¤

Adjusted for age, sex, and calendar period.

#

Test for homogeneity.