Table 2. Metabolic changes after one week treatment with sertraline and placebo.

Compound	Pathway	Sertraline			Placebo			Comparison
		Change	P-value	Q-value	Change	P-value	Q-value	P-value	Q-value
TRPOL	Tryptophan	0.033	0.74	0.64	−0.21	0.016	0.062	0.062	0.8
5-HT	Tryptophan	−0.75	2.8E-12	2.4E-10	−0.21	0.014	0.062	4.7E-06	5.5E-04
5-HIAA	Tryptophan	−0.17	0.00041	0.011	−0.036	0.40	0.45	0.031	0.67
5-HTP	Tryptophan	−0.11	0.21	0.34	−0.019	0.84	0.63	0.49	0.91
5-MTPOL	Tryptophan	0.041	0.50	0.52	0.016	0.81	0.62	0.78	0.94
5-MTPM	Tryptophan	−1.8	0.075	0.22	−2.2	0.031	0.090	0.31	0.91
KYN	Tryptophan	−0.045	0.23	0.35	0.043	0.21	0.29	0.084	0.80
NA-5-HT	Tryptophan	0.0079	0.90	0.71	0.06	0.35	0.41	0.56	0.91
TRP	Tryptophan	0.0036	0.92	0.71	0.063	0.067	0.14	0.23	0.86
3-OHKY	Tryptophan	−0.074	0.20	0.34	0.096	0.087	0.16	0.035	0.67
MEL	Tryptophan	0.34	0.10	0.23	0.3	0.22	0.30	0.89	0.97
LD	Tyrosine	0.081	0.37	0.43	−0.22	0.043	0.11	0.032	0.67
HVA	Tyrosine	0.053	0.46	0.48	0.019	0.8	0.62	0.74	0.94
VMA	Tyrosine	0.11	0.029	0.13	0.041	0.41	0.45	0.31	0.91
DOPAC	Tyrosine	−0.13	0.22	0.34	0.051	0.67	0.59	0.26	0.86
MHPG	Tyrosine	−0.17	0.33	0.42	0.051	0.82	0.62	0.43	0.91
TYR	Tyrosine	0.083	0.10	0.23	0.11	0.024	0.073	0.68	0.92
3-OMD	Tyrosine	−0.12	0.16	0.30	0.14	0.17	0.26	0.05	0.73
4-HPAC	Tyrosine	0.29	0.0044	0.057	0.15	0.072	0.15	0.26	0.86
DIOHMAL	Tyrosine	0.18	0.091	0.23	0.25	0.0057	0.032	0.59	0.91
HGA	Tyrosine	0.28	0.015	0.10	0.27	2.5E-05	0.0019	0.93	0.97
XAN	Purine	−0.19	0.029	0.13	−0.25	0.00017	0.0045	0.56	0.91
HX	Purine	−0.07	0.38	0.44	−0.22	0.0043	0.032	0.17	0.86
GR	Purine	−0.23	0.31	0.40	−0.13	0.56	0.56	0.76	0.94
7-MXAN	Purine	−0.099	0.74	0.64	−0.1	0.72	0.59	0.99	0.98
GRMP	Purine	−0.011	0.90	0.71	−0.033	0.69	0.59	0.85	0.97
XANTH	Purine	0.082	0.16	0.30	−0.022	0.62	0.59	0.15	0.86
UA	Purine	−0.077	0.0061	0.057	0.011	0.71	0.59	0.032	0.67
METH	One Carbon Metabolism	0.097	0.084	0.23	0.14	0.056	0.13	0.64	0.91
4-HPLA	Phenylalanine	0.1	0.0049	0.057	0.095	0.0044	0.032	0.83	0.97
4-HBAC	Phenylalanine	−0.085	0.77	0.65	0.19	0.46	0.49	0.48	0.91
ATOCO	Antioxidant	0.21	0.29	0.40	0.48	0.0048	0.032	0.27	0.86
DTOCO	Antioxidant	0.3	0.30	0.40	0.5	0.039	0.10	0.60	0.91
CYS	Cysteine, Glutathione	−0.034	0.21	0.34	0.039	0.25	0.32	0.089	0.8
GSH	Cysteine, Glutathione	−0.013	0.44	0.47	−0.0067	0.72	0.59	0.81	0.96

Changes in absolute concentrations of metabolites (log-transformed) after one week are shown; positive values – up-regulated metabolites, negative values– down-regulated metabolites. Significant changes are shown in bold. See methods section for the details of statistical analysis. Abbreviations: 5-MTPM – 5-methoxytryptamine; for the remaining metabolites, see Table 1.