Figure 5. Fgf10+/−; Mlc1v-LacZ+/− lungs display reduced alveolar smooth muscle cell formation.
(A, B) Immuno-histochemistry with α-smooth muscle alpha actin (α-SMA) antibody in control (A) and Fgf10+/−; Mlc1v-LacZ+/− P1 lung sections (B). Note the drastic decrease in α-SMA in the respiratory airways of the mutant lung. (C, D) Corresponding staining for Gelatinase activity (see Materials and Methods for details) in control (C) and Fgf10+/−; Mlc1v-LacZ+/− lungs (D). Note the decrease in Gelatinase activity in the mutant lung, especially around the bronchi (arrows) and in the respiratory airway.