Table 1.
Characteristics of the study subjects
| HUMANS | RATS | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| WD-Y (n=5) | WD-M (n=10) | CR (n=15) | P value | AL (n=27) | CR (n=27) | P value | |
| Age (years) | 31.2±2.0 | 58.0±7.4 | 58.7±7.4 | 0.810 | 1.3 | 1.3 | - |
| Sex (M/F) | 5/0 | 8/2 | 11/4 | - | 27/0 | 27/0 | |
| BODY COMPOSITION | |||||||
| Height (m) | 1.73±8.8 | 1.76±0.0 | 1.73±0.0 | 0.409 | - | - | - |
| Body weight (kg) | 78.4±16.3 | 78.1±9.7 | 57.5±6.4 | <0.0001 | 0.40±0.7 | 0.24±0.2 | 0.001 |
| Body mass index (kg/m2) | 25.0±5.0 | 25.3±2.3 | 19.2±1.1 | <0.0001 | - | - | - |
| DEXA - NMR | |||||||
| Fat mass (%) | - | 24.0±7.4 | 13.1±4.8 | <0.0001 | 30.1±0.2 | 27.2±0.2 | 0.01 |
| Trunk fat (%) | - | 25.6±6.8 | 11.0±3.5 | <0.0001 | - | - | - |
| Lean mass (%) | - | 73.1±6.0 | 81.1±4.8 | 0.001 | 60.1±0.2 | 63.1±0.1 | 0.03 |
Values are mean ± SD. WD-Y=younger individuals eating Western diets (WD); WD-M=middle-aged individuals on WD; AL=ad libitum laboratory diet. For humans, p-value comparison CR – WD-M.