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. Author manuscript; available in PMC: 2013 Jul 17.
Published in final edited form as: CNS Neurol Disord Drug Targets. 2013 Jun 14;12(4):466–473. doi: 10.2174/1871527311312040005

Fig. (3). Long-term_increases in cAMP and P-CREB accompany antidepressant treatment.

Fig. (3)

Chronic, but not acute, antidepressant treatment enhances cAMP signaling by increasing Gαs-adenylyl cyclase coupling. Likewise, n-3 PUFAs also increase BDNF, a neurotropic factor increased with CREB phosphorylation, perhaps through enhancement of G-protein signaling. Modified from [50].