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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Hum Mutat. 2013 May 8;34(8):1102–1110. doi: 10.1002/humu.22339

Figure 2.

Figure 2

A Pou3f4 nonsense mutation leads to deafness in an ENU-derived mutant mouse, schwindel (sdl). A: Sanger sequencing chromatogram of a portion of the wild-type mouse Pou3f4 sequence and the corresponding region of the mutation in the Pou3f4sdl/Pou3f4sdl mouse. B: The c.900T>A mutation is predicted to lead to a stop codon, p.Cys300*. The upper scheme represents the one exon structure of the Pou3f4 gene. The bottom schemes represent the full-length protein and the predicted truncated form.