Fig. 15.

A gradient map of UBC distribution in rat (a, c, e) and mouse (b, d, f) cerebella. A parasagittal section from midline is illustrated. The red colored areas represent regions with the highest density (max) of UBCs. The deep blue colored area contain hardly any UBCs. a, b Distribution of all UBCs based on Tbr2 immunolabeling. In both species dense UBC population is associated with the vestibulocerebellum; the Xvent contained the highest UBC density. c, d Distribution of type I UBCs based on CR immunostaining. The distribution is shown in proportion to the total Tbr2⁺ UBC number. Type I UBCs are constrained to nodulus and ventral uvula (IXc/d;r2&3 in rat and IXc;r2 in mouse). In both species few type I UBC are present in the lingula; in rat also in the rest of the uvula. Arrows points to areas with moderate type I UBCs density in VI. e, f Distribution of type II UBCs based on mGluR1α⁺ immunostaining. The distribution is shown in proportion to the total Tbr2⁺ UBC number. The type II UBCs are more widespread then the type I UBCs (compare panel e and f to panel c and d, respectively). They are present not only in nodulus and ventral uvula (IXc/d;r2&3 in rat and IXc;r2 in mouse) but in many other lobules, including the lingula and the rest of the uvula. In both species type II UBCs are rare in IV, V and VIa. Asterisk mark a distinct area in uvula between IXa and IXb. In rat the number of UBC is significantly decreased in this area, especially when compared to the surrounding areas (a, c, e). In mouse this area is completely void of UBCs (b, d, f). Arrowheads (a, b, e, f) point to the tz III to IV that usually contains several type II, but not type I UBCs.