Table 2.
SNP | Ethnicity | N. | Dominant model | Recessive model | Ht vs WT Ho | VR vs WT Ho | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR(95% CI) | Pa | OR(95% CI) | Pa | OR(95% CI) | Pa | OR(95% CI) | Pa | ||||||
rs1501299G/T | Total | 8 | 0.94[0.83,1.05] | 0.27 | 0.94[0.77,1.15] | 0.26 | 0.94[0.83,1.06] | 0.36 | 0.92[0.75,1.12] | 0.25 | |||
Asian | 3 | 0.83[0.68,1.00] | 0.38 | 0.78[0.57,1.06] | 0.98 | 0.84[0.68,1.03] | 0.78 | 0.72[0.52,0.99] | 0.92 | ||||
Caucasian | 4 | 1.01[0.86,1.18] | 0.26 | 1.22[0.92,1.62] | 0.78 | 0.97[0.82,1.15] | 0.26 | 1.20[0.89,1.61] | 0.66 | ||||
African-American | 1 | 1.05[0.72,1.53] | - | 0.63[0.36,1.13] | - | 1.17[0.79,1.74] | - | 0.69[0.37,1.27] | - | ||||
rs2241766T/G | Total | 5 | 1.12[0.89,1.40] | 0.09 | 1.07[0.80,1.43] | 0.30 | 1.22[1.05,1.43] | 0.98 | 1.16[0.86,1.56] | 0.31 | |||
Asian | 3 | 0.99[0.65,1.50]# | 0.02 | 1.36[0.96,1.93] | 0.70 | 1.20[0.98,1.46] | 0.92 | 1.36[0.94,1.97] | 0.91 | ||||
Caucasian | 2 | 1.19[0.94,1.52] | 0.78 | 0.77[0.45,1.30] | 0.28 | 1.27[0.99,1.63] | 0.88 | 0.83[0.48,1.41] | 0.28 | ||||
rs266729C/G | Total | 5 | 0.99[0.90,1.09] | 0.19 | 0.98[0.79,1.22] | 0.83 | 0.96[0.85,1.10] | 0.19 | 0.98[0.78,1.22] | 0.53 | |||
Asian | 3 | 1.09[0.96,1.24] | 0.73 | 1.10[0.80,1.51] | 0.99 | 1.14[0.93,1.40] | 0.70 | 1.18[0.84,1.65] | 0.91 | ||||
Caucasian | 2 | 0.85[0.73,1.00] | 0.79 | 0.89[0.66,1.20] | 0.46 | 0.86[0.72,1.01] | 0.82 | 0.84[0.62,1.14] | 0.82 | ||||
rs822395A/C | Total | 3 | 1.00[0.85,1.19] | 0.33 | 0.83[0.59,1.18] | 0.39 | 1.00[0.76,1.30] | 0.11 | 0.92[0.64,1.32] | 0.56 | |||
Asian | 2 | 0.88[0.70,1.12] | 0.79 | 1.42[0.61,3.31] | 0.81 | 0.86[0.67,1.10] | 0.72 | 1.38[0.59,3.22] | 0.82 | ||||
Caucasian | 1 | 1.14[0.90,1.46] | - | 0.75[0.51,1.10] | - | 1.25[0.96,1.62] | - | 0.84[0.56,1.25] | - | ||||
rs822396A/G | Total | 3 | 1.05[0.87,1.25] | 0.65 | 1.00[0.55,1.82] | 0.67 | 1.05[0.87,1.26] | 0.75 | 1.02[0.56,1.86] | 0.64 | |||
Asian | 2 | 0.97[0.76,1.24] | 0.83 | 0.70[0.25,1.93] | 0.90 | 0.99[0.77,1.27] | 0.84 | 0.70[0.25,1.93] | 0.90 | ||||
Caucasian | 1 | 1.15[0.88,1.50] | - | 1.23[0.59,2.58] | - | 1.14[0.86,1.50] | - | 1.27[0.60,2.68] | - |
N.: number of studies; aTest for heterogeneity. # Random-effect model was used when the P for heterogeneity test was ≤ 0.05, otherwise the fixed-effect model was used. CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; Ht+VR Ho vs. WT Ho, dominant model; VR Ho vs. Ht+WT Ho, recessive model.