Table 3.
Analysis of expression levels of Pkp1 and Krt15 genes
| Expression level | Data | n | Total n* | % | MOS (months) | % survivors | p-value** | p-value*** | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Pkp1 | Higher expression | Microarray | 30 | 43 | 72.9 | 30.4 | 74.4 | 0.221 | AC | 0.121 |
| qPCR | 13 | |||||||||
| No change | Microarray | 10 | 12 | 20.3 | 36.5 | 75 | ||||
| qPCR | 2 | SCC | 0.564 | |||||||
| Lower expression | Microarray | 0 | 4 | 6.8 | 16.75 | 50 | ||||
| qPCR | 4 | |||||||||
| Krt15 | Higher expression | Microarray | 35 | 51 | 86.4 | 30.9 | 72.5 | 0.610 | AC | 0.512 |
| qPCR | 16 | |||||||||
| No change | Microarray | 4 | 6 | 10.1 | 25.6 | 66.7 | ||||
| qPCR | 2 | SCC | - | |||||||
| Lower expression | Microarray | 1 | 2 | 3.4 | 37 | 100 | ||||
| qPCR | 1 | |||||||||
n = number of samples; % = % of study sample of 59 patients; MOS = median overall survival; AC = adenocarcinoma; SCC = squamous cell carcinoma.
**p-values for the relationship between expression levels and survival, calculated using the Log-Rank test.
***p-values for the relationship between expression levels as a function of carcinoma type and survival, calculated using the Log-Rank test.