Figure 1.

D1 antagonism or D2 agonism restore goal-directed behavior. (A) Experimental timeline. Mice only received infusions of drugs during counterbalanced test sessions. One half of mice received the degraded session first while other mice received a non-degraded session first. (B) Only mice whose cannulae were placed within the IL were included in analyses. Images modified from Paxinos and Franklin (2001). (C) Inhibition of D1 signaling with SCH23390 or agonism of the D2 receptor with quinpirole in the IL resulted in reduced responding only during the degraded session, consistent with restoration of goal-directed behavior. Error bars ±SEM. ^*p < 0.05.